Magnesium hydroxide regulates the release of BSA-PLGA microspheres in vitro
Drug delivery systems are an important part of modern medicine, among which poly (D, L-lactic-co-glycolic acid) (PLGA) microspheres are widely studied as a sustained-release carrier. This study explored the application of magnesium hydroxide in regulating the drug release characteristics of BSA-PLGA microspheres.
Research background
PLGA microspheres: a biodegradable and biocompatible polymer suitable for drug delivery.
BSA: used as a model drug to study encapsulation and release behavior.
Magnesium hydroxide: an additive used to regulate the release characteristics of microspheres.
Preparation method
Process flow: BSA-PLGA microspheres were prepared by water-in-oil-in-solid emulsion method.
Addition of magnesium hydroxide: BSA and dextran were prepared into vitreous particles, mixed with magnesium hydroxide and then encapsulated in PLGA.
Characterization technology: SEM was used to observe the morphology of microspheres, and the Micro BCA method was used to determine the encapsulation efficiency and drug loading.
Research results
Microsphere characteristics: The microspheres were about 60 μm in size, with good morphology and spherical shape.
Encapsulation efficiency and drug loading: After adding magnesium hydroxide, the encapsulation efficiency and drug loading of BSA microspheres were significantly improved.
In vitro release: The cumulative release of microspheres containing magnesium hydroxide reached (85.10± 2.67)% within 14 days, which was better than the control group.
Effect of magnesium hydroxide
Different contents of magnesium hydroxide had a significant effect on the encapsulation efficiency and drug loading of microspheres.
Optimized release: By adjusting the content of magnesium hydroxide, BSA microspheres with complete morphology, uniform size and small burst release can be prepared.
Application potential: The research is of great significance for the development of drug delivery systems with controlled release characteristics.